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The Depletion Report.

One smart edit. Once a week.

Bloodwork-literate writing for U.S. women — from the editorial team at Heme. No "10 reasons you're tired" listicles, no affiliate-laundered supplement pitches. One careful, properly-reviewed piece each Sunday.

What you'll get.

  1. 01 One careful editorial each week — not a newsletter blast. We publish one piece each Sunday, edited and clinically reviewed, on a single bloodwork or women's-health question worth your full attention.
  2. 02 Biomarker patterns most often connected to women's energy, cycle and perimenopause — ferritin, full thyroid, vitamin D, B12, the hormone panels, the modern cardiometabolic markers — explained in the language of someone who actually reads labs.
  3. 03 Test comparisons reviewed against published criteria — Function Health, LetsGetChecked, Everlywell, Quest Health and the rest, scored on the same seven-criterion framework. No paid placement, ever.
  4. 04 Provider-conversation prompts — the exact questions worth asking at your next appointment, drawn from the editorial. Print them out, screenshot them, bring them in.
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Edition #12 · Sunday, May 24 2026 6 min read

Why your ferritin probably wasn't checked at your annual.

The marker most directly tied to female fatigue, hair shedding and exercise tolerance is also one of the markers most likely to be left off your standard primary-care order set. Here's why — and what to ask for instead.

If you have walked out of an annual physical in the last decade with a clean bill of health and a vague sense that something isn't right, there is a real chance the reason wasn't checked. The standard primary-care order set in the U.S. typically includes a complete blood count and a basic metabolic panel — but not ferritin. The CBC will catch full-blown iron-deficiency anaemia, where haemoglobin has actually fallen. It will not catch the much more common pattern in women: ferritin under 50 ng/mL, hemoglobin still inside the lab range, and a slow-motion energy deficit that explains the tired.

Ferritin is the storage form of iron. It is the body's reserve tank. When the tank empties, the body cannibalises whatever else it can to keep the haemoglobin numbers up — which is why a CBC can look fine for years while ferritin falls into the single digits. By the time anaemia shows up, the depletion has usually been working its way through your hair follicles, your mitochondria and your thyroid hormone conversion for months. The numbers most clinicians treat — under 12 ng/mL is the textbook deficiency threshold — are usually the bottom of a slide that started a long time before.

What to ask for. "Could we add ferritin and a full iron panel — iron, transferrin, TIBC, transferrin saturation — to my labs?" If the answer is "the CBC was fine," the follow-up is: "I know the CBC was fine. I'd like to see my iron stores specifically, because I have [fatigue, hair shedding, heavy periods, low exercise tolerance] and ferritin can be low for years before the CBC moves." Most clinicians will run it once you ask directly. Some insurance will pay; some won't. If yours won't, a single-condition at-home panel from LetsGetChecked is currently around $79 — cheaper than another year of guessing.

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Who reads The Depletion Report.

I'd been told my labs were "fine" for four years. The Sunday on ferritin walked me through what to actually ask for. My GP ran it that week. I was at 14.

K., 38 · Brooklyn · Reader since edition #04

This is the only women's-health newsletter I read all the way through. No supplement pitches dressed up as editorial. Just careful, properly-reviewed writing about what the labs actually mean.

M., 44 · Austin · Reader since edition #02

The perimenopause edition is the document I wish my OB-GYN had handed me three years ago. I printed it. It's in my purse.

R., 47 · Los Angeles · Reader since edition #07

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Educational only. Not medical advice. Heme is an editorial comparison platform and does not provide medical diagnosis, treatment or emergency advice. Always speak to a qualified healthcare provider about symptoms, blood results or treatment decisions. Some links may be affiliate links. How we make money.