Best thyroid tests compared.

Paloma Health is the most thyroid-literate consumer brand in the U.S. — the company was built around Hashimoto's care and treats the thyroid panel as a serious clinical tool rather than a marketing checkbox. The $89 Complete Thyroid Test covers six markers: TSH, free T3, free T4, reverse T3, and both antibodies (TPO and Tg). That is the panel an endocrinologist would order on a first visit, delivered through a finger-prick kit at home and processed at a CLIA-certified partner lab.

What we like: this is the only at-home test that takes reverse T3 seriously. Reverse T3 is the inactive form of T3 — a high value can suggest your body is converting active hormone into the inactive pathway under stress, low-calorie dieting, or chronic illness. Most consumer panels skip it. Paloma includes it by default, and the result PDF explains the ratio in plain English. The dashboard also tracks markers over time, which matters in autoimmune disease where the trend is more useful than any single number.

What we do not like: the included interpretation is light unless you pay extra. The result PDF is well-formatted but does not replace a clinician conversation. Paloma offers an optional video visit with one of their thyroid-focused MDs for around $99 — worth doing if anything comes back flagged, but it is a separate purchase. Finger-prick collection is also imperfect for women with small veins, though Paloma reships failed kits at no charge.

Best for: women with thyroid symptoms (fatigue, hair shedding, cold intolerance, weight changes, brain fog), anyone with a family history of Hashimoto's or Graves', women already managing a thyroid condition who want a between-appointments check. Worth discussing flagged results with a qualified healthcare provider before adjusting any medication.

LetsGetChecked's Thyroid Plus panel covers five core thyroid markers — TSH, free T3, free T4, and both antibodies — at $129 with a finger-prick kit shipped to your door. The panel itself is one marker narrower than Paloma's (no reverse T3) but the structural advantage here is the included clinician follow-up: if anything comes back flagged, a LetsGetChecked nurse calls within 24 hours to walk through what the result means and what reasonable next steps look like.

What we like: the nurse call is genuinely useful for a first-time thyroid panel. Reading a TSH of 4.8 alongside a positive TPO antibody is not intuitive — a brief clinician conversation translates that into "this looks like early autoimmune thyroid disease and is worth a full workup with your primary care doctor" in a way no PDF can. The result lands in five to seven days and the dashboard tracks results across time.

What we do not like: no reverse T3 and a $40 premium over Paloma. If reverse T3 matters to you (chronic stress, restricted eating, fatigue with normal TSH), Paloma is the more complete panel. LetsGetChecked also asks you to fast for 12 hours before the draw — fine in principle, but easier to mess up than the no-fast Paloma protocol.

Best for: first-time thyroid testers who want a clinician on the other end, women already symptomatic who want a guided conversation about results. Worth discussing flagged results with the clinician who manages your care before changing anything.

Function Health includes a full thyroid panel — TSH, free T3, free T4, reverse T3, TPO antibodies, Tg antibodies — as part of its broader 110-plus marker comprehensive subscription. You will pay materially more than the Paloma or LetsGetChecked single-purchase panels, but you also get an MD review on every result, two annual venous draws, and thyroid context against inflammation markers, iron, vitamin D, and sex hormones — all of which interact with thyroid function in ways a standalone panel cannot show.

What we like: this is the only at-home product that reads thyroid in clinical context. A borderline-low free T3 alongside a low ferritin and a depleted vitamin D reads very differently than the same free T3 in the absence of those deficiencies — and the Function MD review flags the pattern without prompting. The venous draw also removes the finger-prick collection variance that occasionally affects fT3 and fT4 readings.

What we do not like: this is overkill if thyroid is your only question. If you want a thyroid panel and nothing else, Paloma or LetsGetChecked will answer it for one-quarter the annual price. The subscription model is also a real commitment — the value of Function compounds across multiple draws and multiple markers, not in a single thyroid snapshot.

Best for: women who want trending thyroid data alongside a comprehensive picture, anyone with a known thyroid condition managing dose alongside iron, vitamin D, and sex hormones. Discuss flagged results with a qualified healthcare provider, particularly if you are on thyroid replacement.

Everlywell's Thyroid Test is the most widely distributed at-home thyroid panel in the U.S. — available at Target, on Amazon, and via Everlywell directly — at $149 for TSH, free T3, free T4, and TPO antibodies. The kit is well-designed, the dashboard is clean, and the result is reviewed by a physician before being released. For a reader who already shops Everlywell or wants something they can buy in person, the experience is the smoothest of the four reviewed here.

What we like: distribution and onboarding are unusually good. The kit instructions are unambiguous, the collection device is the easiest finger-prick of the four tested, and result PDFs land with a physician sign-off attached. For a first-time at-home tester nervous about doing it wrong, Everlywell removes the most friction.

What we do not like: the panel is narrower than the price suggests. No thyroglobulin antibody (Tg) means the panel cannot rule out the second of the two Hashimoto's-associated antibodies. No reverse T3 means stress-pattern conversion issues will not show. At $149, the same money plus $20 buys the more complete Paloma + Paloma video visit combo, and $20 less buys Paloma alone. Worth knowing what you are paying the premium for.

Best for: readers who want a thyroid panel they can buy at Target tonight, women who already use Everlywell for other tests and want the dashboard in one place. Speak with a qualified healthcare provider about any flagged result, and consider a fuller panel if symptoms persist.